Negative regulation of platelet-derived growth factor receptor signaling pathway

Across TCGA patient cohorts, RNA activity of the Negative regulation of platelet-derived growth factor receptor signaling pathway pathway is significantly associated with the RNA expression of multiple genes, with the PDAC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ESRP2, NEK8, and BCL2A1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of platelet-derived growth factor receptor signaling pathway activity versus ESRP2 in PDAC (Pearson r = -0.34).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PDAC	ESRP2 →	-0.302	-0.188	.003	.006	3	5
PDAC	NEK8 →	-0.235	-0.283	.001	.004	3	5
UCEC	BCL2A1 →	+1.269	+0.424	<.001	.008	3	5
BRCA	TUBB6 →	+0.946	+0.206	.001	.001	3	5
BRCA	C9orf152 →	-1.643	-0.160	.001	.008	3	5
GBM	LGALS1 →	+0.744	+0.181	.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0010642 vs ESRP2 — PDAC

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