Negative regulation of mitochondrial fusion

Across TCGA patient cohorts, RNA activity of the Negative regulation of mitochondrial fusion pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PRICKLE3, EPOP, and TFRC, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of mitochondrial fusion activity versus PRICKLE3 in BRCA (Pearson r = 0.21).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	PRICKLE3 →	+0.411	+0.312	.003	.001	3	5
UCEC	EPOP →	+0.844	+0.602	<.001	.005	3	4
HNSC	TFRC →	+0.814	+0.331	.004	.001	3	4
LSCC	IGF1R →	+0.543	+0.577	.007	.003	3	4
LSCC	POLR2H →	+0.572	+0.571	<.001	<.001	3	4
LSCC	HSD17B10 →	+0.305	+0.575	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0010637 vs PRICKLE3 — BRCA

Explore this scatter interactively →