Regulation of mitochondrial fusion

Across TCGA patient cohorts, RNA activity of the Regulation of mitochondrial fusion pathway is significantly associated with the protein abundance of multiple proteins, with the PDAC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are WASF2_S284, PANK4_T406, and PPP1R12A_S422, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of mitochondrial fusion activity versus WASF2_S284 in PDAC (Pearson r = 0.28).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PDAC	WASF2_S284 →	+0.396	+0.048	.008	.001	3	5
UCEC	PANK4_T406 →	+0.526	+0.061	.001	.009	3	5
PDAC	PPP1R12A_S422 →	-0.307	-0.042	.007	.007	3	5
BRCA	NMNAT1 →	+0.294	+0.030	.001	<.001	3	5
LUAD	PHLDB1_S314 →	+0.650	+0.054	<.001	<.001	3	5
LSCC	HTATSF1_S387 →	+0.407	+0.039	.005	.009	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0010635 vs WASF2_S284 — PDAC

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