Regulation of mitochondrial fusion

Across TCGA cell cohorts, RNA activity of the Regulation of mitochondrial fusion pathway is significantly associated with the RNA expression of multiple genes, with the PANCREAS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are NFU1, VAT1, and SEMA4F, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of mitochondrial fusion activity versus NFU1 in PANCREAS (Pearson r = 0.57).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	NFU1 →	+0.759	+0.344	.006	.001	3	5
LARGE_INTESTINE	VAT1 →	+1.531	+0.206	.002	.008	3	4
OESOPHAGUS	SEMA4F →	+1.288	+0.158	.001	.004	3	4
PANCREAS	DUSP3 →	+0.828	+0.299	<.001	.002	3	4
LUNG_NSCLC_LUAD	RP2 →	+0.765	+0.136	<.001	.007	3	4
BLOOD_Myeloma	ATG13 →	+0.530	+0.200	.008	.001	2	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0010635 vs NFU1 — PANCREAS

Explore this scatter interactively →