Positive regulation of epithelial cell migration

Across TCGA patient cohorts, RNA activity of the Positive regulation of epithelial cell migration pathway is significantly associated with the protein abundance of multiple proteins, with the COAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are REXO1_S459, RPRD2_S1099, and TAF15, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of epithelial cell migration activity versus REXO1_S459 in COAD (Pearson r = -0.28).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	REXO1_S459 →	-0.663	-0.865	.001	<.001	3	1
COAD	RPRD2_S1099 →	-0.314	-1.034	<.001	.001	3	1
COAD	TAF15 →	-0.432	-1.303	.001	<.001	3	1
OV	THRAP3 →	-0.428	-0.270	.002	.002	2	2
COAD	ZSCAN29_S153 →	-0.565	-1.128	<.001	<.001	3	1
COAD	CAPRIN1 →	-0.262	-1.087	<.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0010634 vs REXO1_S459 — COAD

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