Positive regulation of epithelial cell migration

Across TCGA cell cohorts, RNA activity of the Positive regulation of epithelial cell migration pathway is significantly associated with the RNA expression of multiple genes, with the UPPER_AERODIGESTIVE_TRACT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TOGARAM1, TPCN2, and ATP6V1G1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, TOGARAM1 grouped by Positive regulation of epithelial cell migration-low versus -high activity in UPPER_AERODIGESTIVE_TRACT.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	TOGARAM1 →	-1.130	-1.695	.002	<.001	3	3
URINARY_TRACT	TPCN2 →	-0.997	-1.591	<.001	.008	3	3
KIDNEY	ATP6V1G1 →	+0.675	+1.328	<.001	.001	3	3
KIDNEY	MIEN1 →	+0.443	+0.731	.004	.008	3	3
SKIN	UPF2 →	+0.404	+1.047	.004	<.001	3	3
LIVER	RUNDC3A →	+0.285	+1.060	.008	.004	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

TOGARAM1 by Positive regulation of epithelial cell migration activity — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →