Positive regulation of epithelial cell migration

Across TCGA cell cohorts, RNA activity of the Positive regulation of epithelial cell migration pathway is significantly associated with the shRNA dependency of multiple genes, with the BONE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CTLA4, TRIO, and TOMM40, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, CTLA4 grouped by Positive regulation of epithelial cell migration-low versus -high activity in BONE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	CTLA4 →	-0.232	-0.110	.006	.006	3	6
LARGE_INTESTINE	TRIO →	+0.166	+0.069	<.001	<.001	3	5
SKIN	TOMM40 →	-0.387	-0.051	.009	.006	3	5
BONE	HOMER2 →	-0.231	-0.124	.004	.001	3	4
LARGE_INTESTINE	ARHGAP9 →	-0.195	-0.055	<.001	.002	3	4
LUNG_NSCLC_LUAD	TMEM63A →	-0.279	-0.108	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

CTLA4 by Positive regulation of epithelial cell migration activity — BONE

Explore this box plot interactively →