Positive regulation of epithelial cell migration

Across TCGA cell cohorts, RNA activity of the Positive regulation of epithelial cell migration pathway is significantly associated with the RNA expression of multiple genes, with the PANCREAS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SRPX2, FECH, and SLC25A33, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of epithelial cell migration activity versus SRPX2 in PANCREAS (Pearson r = 0.63).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	SRPX2 →	+2.418	+0.269	.003	.002	3	6
LARGE_INTESTINE	FECH →	-1.562	-0.372	.001	<.001	2	7
SKIN	SLC25A33 →	-0.821	-0.216	.005	.001	3	5
PANCREAS	PLAUR →	+2.251	+0.320	<.001	.002	3	5
OESOPHAGUS	ATP5MC2 →	-0.548	-0.195	.002	<.001	3	5
SOFT_TISSUE	NDUFV1 →	-0.553	-0.222	<.001	.007	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0010634 vs SRPX2 — PANCREAS

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