Negative regulation of epithelial cell migration

Across TCGA patient cohorts, RNA activity of the Negative regulation of epithelial cell migration pathway is significantly associated with the RNA expression of multiple genes, with the COAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CNRIP1, GIMAP7, and KANK3, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of epithelial cell migration activity versus CNRIP1 in COAD (Pearson r = 0.03).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	CNRIP1 →	+0.757	+0.144	<.001	<.001	3	6
COAD	GIMAP7 →	+0.765	+0.120	.001	.003	3	6
CCRCC	KANK3 →	+0.999	+0.250	<.001	.001	3	6
CCRCC	SH2D3C →	+0.753	+0.353	<.001	<.001	3	6
LSCC	NLRP1 →	+0.790	+0.192	<.001	<.001	3	5
BRCA	FOXM1 →	-1.120	-0.209	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0010633 vs CNRIP1 — COAD

Explore this scatter interactively →