Negative regulation of epithelial cell migration

Across TCGA pan-cancer cohorts, RNA activity of the Negative regulation of epithelial cell migration pathway is associated with patient survival in 22 of 34 cancer lineages. Pathway activity is summarized from the expression of its 103 member genes.

The strongest signal is observed in kidney renal papillary cell carcinoma (KIRP), where higher Negative regulation of epithelial cell migration pathway activity is associated with poorer overall survival. In most high-consensus cancer types, elevated pathway activity shows an unfavorable survival association, although some cancer types, such as LUAD and MESO, show the opposite pattern, with higher activity associated with better survival.

KIRP, ACC, and LGG are the cancer lineages in which this pathway most reproducibly stratifies patient survival.

Pathway-activity survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 represent the survival AUCs for the high- and low-pathway-activity groups, respectively. The group with the lower AUC is interpreted as having poorer survival. The reported p-values are derived from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRP	OS	Tertile	II,III,IV	0.125	0.648	<.001	71	view →
ACC	OS	Median	III,IV	0.558	0.854	.002	53	view →
LGG	OS	Median	All	0.710	0.887	<.001	53	view →
STAD	OS	Tertile	All	0.509	0.652	.008	35	view →
UVM	OS	Quartile	All	0.348	1.000	.005	24	view →
LUSC	OS	Quartile	All	0.272	0.462	.012	21	view →
LUAD	OS	Median	II,III,IV	0.669	0.509	.027	20	view →
THYM	OS	Median	All	0.937	1.000	.009	18	view →
DLBC	DFS	Median	IV	0.128	1.000	.017	15	view →
MESO	DFS	Quartile	IV	0.800	0.224	.006	12	view →
HNSC	DFS	Quartile	III,IV	0.409	0.283	.023	11	view →
SKCM	OS	Quartile	II,III,IV	0.584	0.309	.004	11	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 22 lineages.

GO:0010633–KIRP (OS)

Open the KIRP breakdown →