Negative regulation of epithelial cell migration

Across TCGA cell cohorts, RNA activity of the Negative regulation of epithelial cell migration pathway is significantly associated with the RNA expression of multiple genes, with the PANCREAS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are NIBAN1, LY75, and COX10, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, NIBAN1 grouped by Negative regulation of epithelial cell migration-low versus -high activity in PANCREAS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	NIBAN1 →	+1.413	+1.084	.002	<.001	3	3
BLOOD_Lymphoma	LY75 →	-2.446	-2.211	<.001	.001	3	3
URINARY_TRACT	COX10 →	+1.079	+1.918	.009	<.001	3	3
STOMACH	FXR1 →	+0.881	+0.387	.001	.002	3	3
LIVER	ZMIZ1 →	-2.436	-1.930	<.001	<.001	3	3
LIVER	TSHZ1 →	-1.355	-1.413	.004	.006	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

NIBAN1 by Negative regulation of epithelial cell migration activity — PANCREAS

Explore this box plot interactively →