Negative regulation of epithelial cell migration

Across TCGA cell cohorts, RNA activity of the Negative regulation of epithelial cell migration pathway is significantly associated with the shRNA dependency of multiple genes, with the PANCREAS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TEF, STK19, and PEX5, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, TEF grouped by Negative regulation of epithelial cell migration-low versus -high activity in PANCREAS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	TEF →	+0.273	+0.077	.003	.003	3	4
SOFT_TISSUE	STK19 →	+0.254	+0.106	.003	.005	3	4
CNS	PEX5 →	+0.140	+0.076	.002	.001	3	4
LUNG_NSCLC_LUSC	IER3IP1 →	+0.260	+0.122	<.001	<.001	3	4
STOMACH	PHACTR2 →	-0.268	-0.188	<.001	<.001	3	3
STOMACH	MBOAT7 →	-0.242	-0.183	.002	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

TEF by Negative regulation of epithelial cell migration activity — PANCREAS

Explore this box plot interactively →