Negative regulation of epithelial cell migration

Across TCGA cell cohorts, RNA activity of the Negative regulation of epithelial cell migration pathway is significantly associated with the shRNA dependency of multiple genes, with the OVARY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are DHTKD1, OR5M10, and MTMR9LP, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, DHTKD1 grouped by Negative regulation of epithelial cell migration-low versus -high activity in OVARY.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	DHTKD1 →	-0.197	-0.309	<.001	<.001	3	4
OVARY	OR5M10 →	+0.364	+0.233	.007	.003	3	4
BLOOD_Leukemia	MTMR9LP →	-0.150	-0.968	.003	.002	3	3
PANCREAS	CFH →	-0.209	-0.412	<.001	.002	3	3
SKIN	CLEC12A →	+0.157	+0.202	<.001	.003	3	3
SKIN	APOL6 →	+0.345	+0.317	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

DHTKD1 by Negative regulation of epithelial cell migration activity — OVARY

Explore this box plot interactively →