Negative regulation of epithelial cell migration

Across TCGA cell cohorts, RNA activity of the Negative regulation of epithelial cell migration pathway is significantly associated with the RNA expression of multiple genes, with the SOFT_TISSUE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SNX27, ZNF333, and DCDC2B, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of epithelial cell migration activity versus SNX27 in SOFT_TISSUE (Pearson r = -0.55).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	SNX27 →	-0.615	-0.306	.001	.002	3	5
BLOOD_Myeloma	ZNF333 →	-1.599	-1.554	.001	.001	3	4
BLOOD_Myeloma	DCDC2B →	-0.095	-1.491	.007	.006	3	4
BLOOD_Myeloma	FAM160A2 →	-0.930	-1.487	.006	.002	3	4
BLOOD_Myeloma	PDK3 →	+0.855	+1.242	.006	.003	3	4
SOFT_TISSUE	TMEM260 →	-0.820	-0.355	.003	.004	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0010633 vs SNX27 — SOFT_TISSUE

Explore this scatter interactively →