Regulation of epithelial cell migration

Across TCGA cell cohorts, RNA activity of the Regulation of epithelial cell migration pathway is significantly associated with the RNA expression of multiple genes, with the OESOPHAGUS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SLC17A5, ZNF287, and ENO2, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, SLC17A5 grouped by Regulation of epithelial cell migration-low versus -high activity in OESOPHAGUS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	SLC17A5 →	+1.542	+1.145	<.001	.007	3	4
UPPER_AERODIGESTIVE_TRACT	ZNF287 →	-1.782	-1.420	<.001	.001	3	3
OVARY	ENO2 →	-2.627	-1.174	<.001	.004	3	3
LARGE_INTESTINE	VAMP1 →	-1.091	-0.807	<.001	.002	3	3
OVARY	PDLIM1 →	-2.312	-1.090	.003	.004	3	3
OVARY	PID1 →	-1.482	-1.234	.005	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

SLC17A5 by Regulation of epithelial cell migration activity — OESOPHAGUS

Explore this box plot interactively →