Negative regulation of Schwann cell proliferation

Across TCGA cell cohorts, RNA activity of the Negative regulation of Schwann cell proliferation pathway is significantly associated with the RNA expression of multiple genes, with the STOMACH cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are OAT, TOMM70, and CORO2A, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, OAT grouped by Negative regulation of Schwann cell proliferation-low versus -high activity in STOMACH.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	OAT →	+0.930	+1.237	.003	<.001	3	4
LUNG_NSCLC_LUAD	TOMM70 →	+0.417	+0.731	<.001	.005	3	4
STOMACH	CORO2A →	+1.330	+1.253	.002	.002	3	3
STOMACH	XPNPEP1 →	+1.053	+1.389	.003	.003	2	4
STOMACH	MMACHC →	-0.895	-0.957	.007	.006	2	4
STOMACH	EIF2A →	+0.989	+1.605	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

OAT by Negative regulation of Schwann cell proliferation activity — STOMACH

Explore this box plot interactively →