Regulation of cytoplasmic mRNA processing body assembly

Across TCGA patient cohorts, RNA activity of the Regulation of cytoplasmic mRNA processing body assembly pathway is significantly associated with the RNA expression of multiple genes, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SNORA30, C9, and RGSL1, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of cytoplasmic mRNA processing body assembly activity versus SNORA30 in OV (Pearson r = 0.28).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	SNORA30 →	+0.374	+0.594	.003	.006	3	3
LUAD	C9 →	-0.138	-0.618	.001	.002	3	3
OV	RGSL1 →	+0.021	+0.585	.005	<.001	3	2
OV	MIR659 →	-0.701	-0.577	.005	.004	3	2
OV	SNORD127 →	+0.813	+0.612	.003	.001	3	2
BRCA	C5orf46 →	-1.232	-0.472	.004	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0010603 vs SNORA30 — OV

Explore this scatter interactively →