Positive regulation of endothelial cell migration

Across TCGA cell cohorts, RNA activity of the Positive regulation of endothelial cell migration pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SLC9A9, GNA15, and EFNB2, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, SLC9A9 grouped by Positive regulation of endothelial cell migration-low versus -high activity in LUNG_NSCLC_LUAD.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	SLC9A9 →	-0.831	-0.210	<.001	<.001	3	4
LUNG_NSCLC_LUAD	GNA15 →	-1.417	-0.160	.007	<.001	3	4
BREAST	EFNB2 →	-1.967	-0.222	.001	<.001	3	4
LUNG_NSCLC_LUAD	HTR7 →	-1.173	-0.140	.001	.002	2	4
BREAST	RELB →	-1.277	-0.193	.003	.001	3	3
UPPER_AERODIGESTIVE_TRACT	MDFI →	-1.396	-0.232	.004	.006	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

SLC9A9 by Positive regulation of endothelial cell migration activity — LUNG_NSCLC_LUAD

Explore this box plot interactively →