Positive regulation of endothelial cell migration

Across TCGA cell cohorts, RNA activity of the Positive regulation of endothelial cell migration pathway is significantly associated with the RNA expression of multiple genes, with the SKIN cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PLP2, HOXB7, and MYO1C, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of endothelial cell migration activity versus PLP2 in SKIN (Pearson r = 0.55).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	PLP2 →	+1.212	+0.215	.001	.001	3	6
SKIN	HOXB7 →	+1.046	+0.193	<.001	.007	3	6
BREAST	MYO1C →	+0.717	+0.201	.002	.005	3	5
BREAST	CAPZB →	+0.846	+0.216	<.001	.005	3	5
STOMACH	FAM156B →	+0.698	+0.248	.001	.005	3	5
OVARY	CTIF →	+1.307	+0.250	.002	.002	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0010595 vs PLP2 — SKIN

Explore this scatter interactively →