Positive regulation of lamellipodium assembly

Across TCGA patient cohorts, RNA activity of the Positive regulation of lamellipodium assembly pathway is significantly associated with the RNA expression of multiple genes, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ZEB2, RBMS1, and SNAI2, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of lamellipodium assembly activity versus ZEB2 in OV (Pearson r = 0.36).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	ZEB2 →	+0.688	+0.125	.001	<.001	3	6
PDAC	RBMS1 →	+0.400	+0.111	<.001	<.001	3	5
CCRCC	SNAI2 →	+0.707	+0.140	.008	.001	3	5
LSCC	CD209 →	+0.684	+0.102	<.001	.001	3	5
LSCC	TGFB1 →	+0.571	+0.134	.003	<.001	3	5
LSCC	GALNT15 →	+0.817	+0.147	.002	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0010592 vs ZEB2 — OV

Explore this scatter interactively →