Positive regulation of lamellipodium assembly

Across TCGA pan-cancer cohorts, RNA activity of the Positive regulation of lamellipodium assembly pathway is associated with patient survival in 20 of 34 cancer lineages. Pathway activity is summarized from the expression of its 28 member genes.

The strongest signal is observed in uveal melanoma (UVM), where higher Positive regulation of lamellipodium assembly pathway activity is associated with poorer disease-free survival. In most high-consensus cancer types, elevated pathway activity shows an unfavorable survival association, although some cancer types, such as UCS and ESCA, show the opposite pattern, with higher activity associated with better survival.

UVM, UCS, and KICH are the cancer lineages in which this pathway most reproducibly stratifies patient survival.

Pathway-activity survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 represent the survival AUCs for the high- and low-pathway-activity groups, respectively. The group with the lower AUC is interpreted as having poorer survival. The reported p-values are derived from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UVM	DFS	Median	All	0.406	0.712	<.001	111	view →
UCS	DFS	Median	II,III,IV	0.472	0.159	.011	38	view →
KICH	DFS	Median	II,III,IV	0.474	0.878	.001	34	view →
ESCA	OS	Tertile	III,IV	0.717	0.305	.005	24	view →
READ	DFS	Median	IV	0.330	0.761	<.001	21	view →
PAAD	DFS	Tertile	All	0.241	0.444	.004	20	view →
BLCA	DFS	Median	II,III,IV	0.568	0.657	.006	20	view →
LUSC	DFS	Median	All	0.801	0.707	.015	16	view →
CHOL	DFS	Tertile	All	0.640	0.098	.003	16	view →
ACC	DFS	Quartile	All	0.308	0.797	.017	13	view →
LGG	DFS	Median	All	0.322	0.493	.007	12	view →
KIRP	OS	Quartile	All	0.786	0.928	.005	10	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 20 lineages.

GO:0010592–UVM (DFS)

Open the UVM breakdown →