Positive regulation of lamellipodium assembly

Across TCGA cell cohorts, RNA activity of the Positive regulation of lamellipodium assembly pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are THBS1, CBS, and MARS2, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, THBS1 grouped by Positive regulation of lamellipodium assembly-low versus -high activity in LUNG_NSCLC_LUSC.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	THBS1 →	+3.816	+0.474	<.001	.004	3	7
OVARY	CBS →	-2.295	-0.596	.003	.003	3	5
OVARY	MARS2 →	-0.566	-0.405	.007	.002	2	6
LARGE_INTESTINE	CTSZ →	+1.595	+0.688	.004	.006	3	5
LARGE_INTESTINE	TGFBI →	+4.285	+0.978	<.001	<.001	3	5
STOMACH	TBC1D2 →	+1.723	+0.971	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

THBS1 by Positive regulation of lamellipodium assembly activity — LUNG_NSCLC_LUSC

Explore this box plot interactively →