Positive regulation of lamellipodium assembly

Across TCGA cell cohorts, RNA activity of the Positive regulation of lamellipodium assembly pathway is significantly associated with the RNA expression of multiple genes, with the PANCREAS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TWF2, RAC2, and PRXL2C, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of lamellipodium assembly activity versus TWF2 in PANCREAS (Pearson r = 0.59).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	TWF2 →	+0.692	+0.299	<.001	<.001	3	6
KIDNEY	RAC2 →	+2.831	+0.259	.007	.008	2	7
SKIN	PRXL2C →	+0.595	+0.214	.004	<.001	3	6
SKIN	ARPC4 →	+0.595	+0.176	<.001	.007	3	6
SOFT_TISSUE	CARD19 →	+1.312	+0.291	.008	.002	3	5
PANCREAS	EIF2AK4 →	+0.754	+0.362	.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0010592 vs TWF2 — PANCREAS

Explore this scatter interactively →