miRNA catabolic process

Across TCGA patient cohorts, RNA activity of the miRNA catabolic process pathway is significantly associated with the RNA expression of multiple genes, with the CCRCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RASGRF2, LBH, and A2M, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, miRNA catabolic process activity versus RASGRF2 in CCRCC (Pearson r = -0.23).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	RASGRF2 →	-0.737	-0.223	<.001	<.001	3	5
PDAC	LBH →	-0.433	-0.196	<.001	.004	3	4
CCRCC	A2M →	-0.551	-0.265	<.001	.003	3	4
CCRCC	RUNX1T1 →	-0.583	-0.117	.002	.009	3	4
BRCA	SPARCL1 →	-0.995	-0.265	.002	.006	3	4
PDAC	SEPTIN4 →	-0.441	-0.229	.001	.007	2	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0010587 vs RASGRF2 — CCRCC

Explore this scatter interactively →