miRNA metabolic process

Across TCGA patient cohorts, RNA activity of the miRNA metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are DKK1, RPS6KA1, and RNASE1, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, miRNA metabolic process activity versus DKK1 in BRCA (Pearson r = -0.09).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	DKK1 →	-1.222	-0.858	.003	.001	3	2
BRCA	RPS6KA1 →	-0.551	-0.855	<.001	.002	3	2
BRCA	RNASE1 →	-0.939	-0.716	<.001	.005	3	2
BRCA	CREBZF →	+0.703	+0.781	<.001	.007	3	2
BRCA	TMEM65 →	-0.406	-0.575	.003	.008	3	2
BRCA	RLN3 →	-0.197	-0.750	.006	.005	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0010586 vs DKK1 — BRCA

Explore this scatter interactively →