Positive regulation of platelet activation

Across TCGA cell cohorts, RNA activity of the Positive regulation of platelet activation pathway is significantly associated with the drug response of multiple features, with the BLOOD_Lymphoma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated features across cancer lineages are WIKI4, CT7033-2, and IGF1R_3801, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, WIKI4 grouped by Positive regulation of platelet activation-low versus -high activity in BLOOD_Lymphoma.

Pathway-associated features by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner feature	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	WIKI4 →	-0.550	-0.532	.011	.012	3	2
BLOOD_Leukemia	CT7033-2 →	+0.511	+0.359	.027	.004	3	2
BLOOD_Lymphoma	IGF1R_3801 →	-1.890	-0.546	<.001	.011	3	2
BLOOD_Lymphoma	729189 →	-0.713	-0.546	<.001	.011	3	2
BLOOD_Lymphoma	743380 →	-0.509	-0.396	<.001	.015	3	2
BLOOD_Lymphoma	Sabutoclax →	-1.125	-0.635	.022	.007	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

WIKI4 by Positive regulation of platelet activation activity — BLOOD_Lymphoma

Explore this box plot interactively →