Regulation of ketone biosynthetic process

Across TCGA cell cohorts, RNA activity of the Regulation of ketone biosynthetic process pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are AKR1C1, AKR1C3, and ACOT9, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of ketone biosynthetic process activity versus AKR1C1 in LUNG_NSCLC_LUAD (Pearson r = 0.52).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	AKR1C1 →	+4.637	+0.985	<.001	<.001	3	6
LUNG_NSCLC_LUAD	AKR1C3 →	+3.537	+0.833	<.001	<.001	3	6
LUNG_SCLC	ACOT9 →	-2.787	-0.447	.004	.006	3	5
OVARY	RBX1 →	-0.676	-0.944	.002	.004	3	4
LUNG_NSCLC_LUAD	COQ8B →	+0.707	+0.842	<.001	.007	3	4
LUNG_NSCLC_LUAD	AKR1C2 →	+4.366	+0.824	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0010566 vs AKR1C1 — LUNG_NSCLC_LUAD

Explore this scatter interactively →