Regulation of calcium ion transport into cytosol

Across TCGA cell cohorts, RNA activity of the Regulation of calcium ion transport into cytosol pathway is significantly associated with the RNA expression of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PML, HLA-B, and APOL3, each associated with the pathway in up to 11 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of calcium ion transport into cytosol activity versus PML in BREAST (Pearson r = 0.49).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	PML →	+1.640	+1.299	<.001	<.001	3	11
PANCREAS	HLA-B →	+3.518	+0.497	<.001	.002	3	11
PANCREAS	APOL3 →	+2.344	+0.468	.001	.003	3	10
BREAST	IRF1 →	+2.082	+0.996	<.001	<.001	3	10
CNS	IFI44 →	+2.576	+0.346	.002	.002	3	10
LUNG_NSCLC_LUSC	ADRB2 →	+2.618	+0.409	<.001	.001	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0010522 vs PML — BREAST

Explore this scatter interactively →