Regulation of phospholipase activity

Across TCGA cell cohorts, RNA activity of the Regulation of phospholipase activity pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are FGFR1, TTC28, and MSRB3, each associated with the pathway in up to 17 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of phospholipase activity activity versus FGFR1 in LUNG_NSCLC_LUSC (Pearson r = 0.64).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	FGFR1 →	+4.198	+0.841	<.001	.006	3	17
LUNG_NSCLC_LUAD	TTC28 →	+0.712	+0.469	.001	.006	3	7
LUNG_NSCLC_LUAD	MSRB3 →	+1.584	+0.676	<.001	<.001	3	7
STOMACH	LRP1 →	+1.331	+0.647	.004	.006	3	6
BLOOD_Myeloma	FGFR3 →	+4.346	+1.463	<.001	<.001	3	6
LUNG_NSCLC_LUAD	MRC2 →	+2.028	+0.757	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0010517 vs FGFR1 — LUNG_NSCLC_LUSC

Explore this scatter interactively →