Positive regulation of autophagy

Across TCGA cell cohorts, RNA activity of the Positive regulation of autophagy pathway is significantly associated with the RNA expression of multiple genes, with the URINARY_TRACT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TMEFF1, SCD5, and CAVIN4, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of autophagy activity versus TMEFF1 in URINARY_TRACT (Pearson r = -0.83).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	TMEFF1 →	-1.532	-0.184	<.001	.002	3	7
BREAST	SCD5 →	-1.560	-0.120	<.001	<.001	3	5
PANCREAS	CAVIN4 →	-0.681	-0.214	.003	<.001	3	5
BREAST	WTIP →	-1.336	-0.108	.001	<.001	3	5
STOMACH	TXNRD3 →	-2.206	-0.229	.003	.004	3	4
BREAST	TMSB15B →	-2.814	-0.164	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0010508 vs TMEFF1 — URINARY_TRACT

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