Regulation of gastrulation

Across TCGA patient cohorts, RNA activity of the Regulation of gastrulation pathway is significantly associated with the RNA expression of multiple genes, with the SCLC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PHLDB1, TMEM198B, and XPC-AS1, each associated with the pathway in up to 27 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of gastrulation activity versus PHLDB1 in SCLC (Pearson r = -0.18).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SCLC	PHLDB1 →	+2.656	+0.091	.004	.004	1	27
KIRP	TMEM198B →	+0.775	+0.037	<.001	<.001	3	24
THYM	XPC-AS1 →	+0.561	+0.038	<.001	<.001	3	24
TGCT	ARPC4-TTLL3 →	+0.323	+0.069	<.001	<.001	3	24
UVM	RPL32P3 →	+0.785	+0.037	<.001	<.001	3	24
KIRP	MSANTD2 →	+0.693	+0.042	<.001	<.001	3	23

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0010470 vs PHLDB1 — SCLC

Explore this scatter interactively →