Regulation of gastrulation

Across TCGA cell cohorts, RNA activity of the Regulation of gastrulation pathway is significantly associated with the RNA expression of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are H3C6, PAICS, and PPAT, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of gastrulation activity versus H3C6 in BREAST (Pearson r = -0.90).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	H3C6 →	-1.995	-0.263	.001	.004	3	3
CNS	PAICS →	+1.628	+0.601	.002	.004	3	3
CNS	PPAT →	+1.816	+0.601	.004	.004	3	3
CNS	CENPC →	+1.029	+0.585	.003	.001	3	3
OVARY	TANGO6 →	+1.647	+0.392	.002	.006	3	3
OVARY	INTS10 →	+1.322	+0.320	<.001	.003	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0010470 vs H3C6 — BREAST

Explore this scatter interactively →