Negative regulation of peptidase activity

Across TCGA cell cohorts, RNA activity of the Negative regulation of peptidase activity pathway is significantly associated with the RNA expression of multiple genes, with the STOMACH cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SET, NLN, and GTPBP8, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, SET grouped by Negative regulation of peptidase activity-low versus -high activity in STOMACH.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	SET →	+0.505	+1.174	<.001	<.001	3	4
STOMACH	NLN →	+0.978	+1.533	<.001	<.001	3	4
URINARY_TRACT	GTPBP8 →	+0.917	+1.712	.001	<.001	3	4
LUNG_SCLC	MRPS14 →	+0.585	+1.038	.006	.006	3	3
OVARY	SSPN →	-1.953	-1.088	<.001	<.001	3	3
OVARY	RABL2A →	-0.885	-0.848	.002	.007	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

SET by Negative regulation of peptidase activity activity — STOMACH

Explore this box plot interactively →