Negative regulation of peptidase activity

Across TCGA cell cohorts, RNA activity of the Negative regulation of peptidase activity pathway is significantly associated with the shRNA dependency of multiple genes, with the PANCREAS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RPS6KL1, ZBTB9, and ITGAV, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, RPS6KL1 grouped by Negative regulation of peptidase activity-low versus -high activity in PANCREAS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	RPS6KL1 →	-0.238	-0.264	.003	.003	3	5
PANCREAS	ZBTB9 →	-0.110	-0.163	.004	.009	3	5
LIVER	ITGAV →	+0.720	+0.393	<.001	<.001	3	5
CNS	NIFK →	-0.204	-0.185	.002	.001	3	5
CNS	FPR2 →	-0.317	-0.225	<.001	<.001	3	5
LUNG_NSCLC_LUSC	LGSN →	+0.276	+0.384	.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

RPS6KL1 by Negative regulation of peptidase activity activity — PANCREAS

Explore this box plot interactively →