Negative regulation of peptidase activity

Across TCGA cell cohorts, RNA activity of the Negative regulation of peptidase activity pathway is significantly associated with the RNA expression of multiple genes, with the CNS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CRYL1, PYGB, and ARFGEF3, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of peptidase activity activity versus CRYL1 in CNS (Pearson r = 0.56).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	CRYL1 →	+1.598	+1.023	.006	.006	3	4
LARGE_INTESTINE	PYGB →	-0.855	-1.467	<.001	<.001	3	3
CNS	ARFGEF3 →	+1.381	+1.184	.002	.002	3	3
CNS	PCID2 →	+0.951	+1.227	.003	.004	3	3
BLOOD_Lymphoma	TBC1D8 →	+2.502	+1.319	<.001	.007	3	3
BLOOD_Lymphoma	ELFN1 →	+0.806	+1.964	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0010466 vs CRYL1 — CNS

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