Regulation of mesenchymal cell proliferation

Across TCGA cell cohorts, RNA activity of the Regulation of mesenchymal cell proliferation pathway is significantly associated with the RNA expression of multiple genes, with the SKIN cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are EPHA2, PRR5, and CUEDC2, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, EPHA2 grouped by Regulation of mesenchymal cell proliferation-low versus -high activity in SKIN.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	EPHA2 →	-1.426	-0.338	.001	.001	3	3
SKIN	PRR5 →	+1.027	+0.327	<.001	.001	3	3
BONE	CUEDC2 →	+0.983	+0.257	.005	.008	3	3
BONE	MAP3K6 →	-1.382	-0.325	.005	.001	3	3
OESOPHAGUS	MOCS1 →	-1.766	-0.367	.004	.002	3	3
UPPER_AERODIGESTIVE_TRACT	GTF2E1 →	-0.949	-0.323	.002	.006	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

EPHA2 by Regulation of mesenchymal cell proliferation activity — SKIN

Explore this box plot interactively →