Regulation of mesenchymal cell proliferation

Across TCGA pan-cancer cohorts, RNA activity of the Regulation of mesenchymal cell proliferation pathway is associated with patient survival in 17 of 34 cancer lineages. Pathway activity is summarized from the expression of its 32 member genes.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher Regulation of mesenchymal cell proliferation pathway activity is associated with better disease-free survival. In most high-consensus cancer types, elevated pathway activity shows an unfavorable survival association, although some cancer types, such as HNSC and ACC, show the opposite pattern, with higher activity associated with better survival.

HNSC, ACC, and LUAD are the cancer lineages in which this pathway most reproducibly stratifies patient survival.

Pathway-activity survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 represent the survival AUCs for the high- and low-pathway-activity groups, respectively. The group with the lower AUC is interpreted as having poorer survival. The reported p-values are derived from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Median	IV	0.658	0.458	<.001	42	view →
ACC	OS	Median	IV	0.884	0.302	<.001	41	view →
LUAD	OS	Median	II,III,IV	0.689	0.511	.015	20	view →
BRCA	OS	Median	III,IV	0.953	0.862	.008	20	view →
UVM	DFS	Quartile	III,IV	1.000	0.409	.022	19	view →
OV	DFS	Quartile	IV	0.266	0.587	.008	18	view →
THYM	DFS	Median	III,IV	1.000	0.494	.015	18	view →
UCS	OS	Quartile	II,III,IV	0.605	0.250	.022	16	view →
LGG	DFS	Median	All	0.286	0.516	.006	9	view →
KIRC	DFS	Quartile	IV	0.300	0.618	.016	8	view →
GBM	DFS	Median	All	0.302	0.216	.036	6	view →
MESO	OS	Tertile	IV	1.000	0.474	.032	6	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 17 lineages.

GO:0010464–HNSC (DFS)

Open the HNSC breakdown →