Regulation of mesenchymal cell proliferation

Across TCGA cell cohorts, RNA activity of the Regulation of mesenchymal cell proliferation pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Lymphoma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ADIPOR1, STAT1, and MED25, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of mesenchymal cell proliferation activity versus ADIPOR1 in BLOOD_Lymphoma (Pearson r = 0.52).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	ADIPOR1 →	+1.405	+1.525	.004	.002	3	6
BLOOD_Lymphoma	STAT1 →	+2.814	+1.455	<.001	<.001	3	5
UPPER_AERODIGESTIVE_TRACT	MED25 →	+0.728	+0.994	.001	.004	3	5
BLOOD_Lymphoma	EMP3 →	+2.453	+1.440	<.001	<.001	3	5
LUNG_SCLC	TMEM253 →	+0.503	+1.454	<.001	<.001	3	4
LUNG_NSCLC_LUAD	NCOA1 →	+0.721	+0.722	.002	.007	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0010464 vs ADIPOR1 — BLOOD_Lymphoma

Explore this scatter interactively →