Mesenchymal cell proliferation

Across TCGA cell cohorts, RNA activity of the Mesenchymal cell proliferation pathway is significantly associated with the RNA expression of multiple genes, with the SOFT_TISSUE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are NEMP2, TAZ, and VBP1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, NEMP2 grouped by Mesenchymal cell proliferation-low versus -high activity in SOFT_TISSUE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	NEMP2 →	-1.229	-1.308	.004	.009	3	4
LUNG_NSCLC_LUAD	TAZ →	-0.576	-0.756	.009	.008	3	4
BONE	VBP1 →	-0.656	-1.173	.001	.002	3	4
LUNG_NSCLC_LUSC	DNAJC14 →	-0.813	-1.021	<.001	.006	3	3
LUNG_NSCLC_LUSC	ZC3HC1 →	-1.174	-1.748	<.001	<.001	3	3
STOMACH	ZNF282 →	-0.674	-0.978	.002	.009	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

NEMP2 by Mesenchymal cell proliferation activity — SOFT_TISSUE

Explore this box plot interactively →