Negative regulation of heart rate

Across TCGA patient cohorts, RNA activity of the Negative regulation of heart rate pathway is significantly associated with the RNA expression of multiple genes, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are BNIP3P32, LOH12CR2, and CLSTN3, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of heart rate activity versus BNIP3P32 in GBM (Pearson r = 0.28).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	BNIP3P32 →	+0.566	+0.983	<.001	<.001	3	4
LSCC	LOH12CR2 →	+0.518	+0.657	<.001	.002	3	3
OV	CLSTN3 →	+1.407	+0.222	<.001	.002	3	3
OV	PIANP →	+0.692	+0.189	.005	.005	3	3
HNSC	SNRPD2P1 →	+0.438	+0.135	.001	.004	3	3
CCRCC	RNU6-1054P →	-0.577	-0.414	.001	.008	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0010459 vs BNIP3P32 — GBM

Explore this scatter interactively →