Exit from mitosis

Across TCGA patient cohorts, RNA activity of the Exit from mitosis pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SMARCD1, DNMT1, and DHX8, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Exit from mitosis activity versus SMARCD1 in GBM (Pearson r = 0.44).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	SMARCD1 →	+0.300	+0.039	<.001	<.001	3	7
LUAD	DNMT1 →	+0.179	+0.040	.006	<.001	3	7
HNSC	DHX8 →	+0.201	+0.090	.003	.001	3	7
GBM	TOP2A →	+0.984	+0.068	<.001	<.001	3	6
LUAD	BRCA1_S114 →	+0.848	+0.062	.001	<.001	3	6
UCEC	DNMT3A →	+0.501	+0.054	<.001	.005	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0010458 vs SMARCD1 — GBM

Explore this scatter interactively →