Centriole-centriole cohesion

Across TCGA patient cohorts, RNA activity of the Centriole-centriole cohesion pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are TOP2A, MCM5, and PSIP1, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Centriole-centriole cohesion activity versus TOP2A in LSCC (Pearson r = 0.35).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	TOP2A →	+0.812	+0.053	.001	.001	3	8
OV	MCM5 →	+0.638	+0.048	.001	<.001	3	8
OV	PSIP1 →	+0.588	+0.046	<.001	.001	3	8
COAD	CEP170 →	+0.327	+0.031	<.001	<.001	3	7
COAD	PRDX5 →	-0.661	-0.036	<.001	<.001	3	7
OV	STMN1 →	+0.708	+0.057	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0010457 vs TOP2A — LSCC

Explore this scatter interactively →