COP9 signalosome assembly

Across TCGA patient cohorts, RNA activity of the COP9 signalosome assembly pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are DTYMK, LARP7, and NCL, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, COP9 signalosome assembly activity versus DTYMK in GBM (Pearson r = 0.39).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	DTYMK →	+0.327	+0.057	<.001	<.001	3	8
OV	LARP7 →	+0.469	+0.067	<.001	.002	3	7
OV	NCL →	+0.710	+0.087	<.001	<.001	3	7
GBM	ARRB1 →	-0.446	-0.071	<.001	<.001	3	6
GBM	TRRAP →	+0.216	+0.054	.001	.002	3	6
GBM	FBP1 →	-0.768	-0.067	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0010387 vs DTYMK — GBM

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