COP9 signalosome assembly

Across TCGA cell cohorts, RNA activity of the COP9 signalosome assembly pathway is significantly associated with the RNA expression of multiple genes, with the KIDNEY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PIK3C3, ISM2, and LRFN1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, PIK3C3 grouped by COP9 signalosome assembly-low versus -high activity in KIDNEY.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
KIDNEY	PIK3C3 →	-0.847	-0.303	<.001	.003	3	4
LUNG_SCLC	ISM2 →	+1.246	+0.551	<.001	<.001	3	3
LUNG_SCLC	LRFN1 →	+2.219	+0.432	.002	<.001	3	3
LUNG_SCLC	C7orf26 →	+0.530	+0.432	.006	<.001	3	3
LUNG_SCLC	IQCD →	-1.273	-0.432	.004	<.001	3	3
LUNG_SCLC	EPHX4 →	+2.083	+0.432	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

PIK3C3 by COP9 signalosome assembly activity — KIDNEY

Explore this box plot interactively →