COP9 signalosome assembly

Across TCGA cell cohorts, RNA activity of the COP9 signalosome assembly pathway is significantly associated with the RNA expression of multiple genes, with the OESOPHAGUS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are DEXI, FAF1, and CFD, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, COP9 signalosome assembly activity versus DEXI in OESOPHAGUS (Pearson r = 0.75).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	DEXI →	+0.593	+1.372	<.001	.003	3	4
OESOPHAGUS	FAF1 →	+1.200	+1.318	.004	.002	3	4
OESOPHAGUS	CFD →	-2.518	-1.431	.003	.002	2	5
UPPER_AERODIGESTIVE_TRACT	LANCL1 →	+1.257	+1.303	<.001	.004	1	6
LUNG_SCLC	CTSD →	-1.027	-0.571	<.001	.001	3	4
BLOOD_Leukemia	APH1A →	-0.439	-0.762	.001	.003	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0010387 vs DEXI — OESOPHAGUS

Explore this scatter interactively →