COP9 signalosome assembly

Across TCGA cell cohorts, RNA activity of the COP9 signalosome assembly pathway is significantly associated with the protein abundance of multiple proteins, with the PANCREAS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are COPS8, COPS4, and COPS6, each associated with the pathway in up to 17 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, COP9 signalosome assembly activity versus COPS8 in PANCREAS (Pearson r = 0.76).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	COPS8 →	+1.518	+1.156	<.001	.005	3	17
UPPER_AERODIGESTIVE_TRACT	COPS4 →	+1.270	+1.254	.005	.008	3	16
SOFT_TISSUE	COPS6 →	+1.096	+1.418	<.001	<.001	3	16
SOFT_TISSUE	PPP2R1A →	+0.989	+1.451	.001	.002	3	14
PANCREAS	PSMB7 →	+1.428	+1.279	<.001	.004	3	14
LIVER	COPS2 →	+1.636	+1.778	.003	<.001	3	14

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0010387 vs COPS8 — PANCREAS

Explore this scatter interactively →