Response to gamma radiation

Across TCGA patient cohorts, RNA activity of the Response to gamma radiation pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TTK, CENPA, and TICRR, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Response to gamma radiation activity versus TTK in BRCA (Pearson r = 0.25).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	TTK →	+0.819	+0.174	.001	.001	3	6
LUAD	CENPA →	+0.602	+0.137	.003	<.001	3	6
LUAD	TICRR →	+0.622	+0.199	<.001	.001	3	6
LUAD	CDCA5 →	+0.904	+0.203	<.001	<.001	3	6
BRCA	CDC25A →	+0.660	+0.208	.001	<.001	3	6
LUAD	KIF18B →	+0.918	+0.193	<.001	.002	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0010332 vs TTK — BRCA

Explore this scatter interactively →