Response to gamma radiation

Across TCGA cell cohorts, RNA activity of the Response to gamma radiation pathway is significantly associated with the RNA expression of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are NBEAL2, FAM160A2, and ZNF439, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, NBEAL2 grouped by Response to gamma radiation-low versus -high activity in BREAST.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	NBEAL2 →	+1.105	+0.110	.001	.007	3	5
STOMACH	FAM160A2 →	+1.106	+0.195	<.001	<.001	3	4
LUNG_SCLC	ZNF439 →	+1.629	+0.215	.004	<.001	3	4
UPPER_AERODIGESTIVE_TRACT	PIAS3 →	+1.372	+0.295	<.001	<.001	3	4
BREAST	SEPTIN8 →	+1.141	+0.203	<.001	<.001	3	4
BREAST	ZNF283 →	+0.769	+0.226	.005	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

NBEAL2 by Response to gamma radiation activity — BREAST

Explore this box plot interactively →