Membrane invagination

Across TCGA patient cohorts, RNA activity of the Membrane invagination pathway is significantly associated with the RNA expression of multiple genes, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MYO1F, TRGV8, and ARHGAP9, each associated with the pathway in up to 10 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Membrane invagination activity versus MYO1F in OV (Pearson r = 0.34).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	MYO1F →	+0.861	+0.185	<.001	.001	3	10
LSCC	TRGV8 →	+0.760	+0.232	<.001	<.001	3	10
UCEC	ARHGAP9 →	+0.719	+0.149	<.001	<.001	3	10
OV	SLCO2B1 →	+0.772	+0.178	.004	<.001	3	10
GBM	PIK3R5 →	+0.691	+0.156	<.001	<.001	3	10
UCEC	BTK →	+1.003	+0.243	<.001	<.001	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0010324 vs MYO1F — OV

Explore this scatter interactively →