Response to lead ion

Across TCGA patient cohorts, RNA activity of the Response to lead ion pathway is significantly associated with the RNA expression of multiple genes, with the COAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SDS, LRRC43, and OR2R1P, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Response to lead ion activity versus SDS in COAD (Pearson r = 0.15).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	SDS →	+0.702	+0.181	.004	.001	3	3
UCEC	LRRC43 →	-0.946	-0.145	<.001	.001	3	3
LUAD	OR2R1P →	-0.468	-0.147	.006	.005	3	3
HNSC	TGFBR2 →	-0.406	-0.138	.004	<.001	3	3
HNSC	KRT10 →	-1.089	-0.118	.009	.002	3	3
GBM	DEPDC1 →	+0.597	+0.082	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0010288 vs SDS — COAD

Explore this scatter interactively →